TocilizumabV1, Main, Exploration, bibRecord, 001444

Comparative effectiveness of tocilizumab versus TNF inhibitors as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis after the use of at least one biologic disease-modifying antirheumatic drug: analyses from the pan-European TOCERRA register collaboration.

Identifieur interne : 001444 ( Main/Exploration ); précédent : 001443; suivant : 001445

Comparative effectiveness of tocilizumab versus TNF inhibitors as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis after the use of at least one biologic disease-modifying antirheumatic drug: analyses from the pan-European TOCERRA register collaboration.

Auteurs : Kim Lauper [Suisse] ; Dan C. Nordström [Finlande] ; Karel Pavelka [République tchèque] ; Maria Victoria Hernández [Espagne] ; Tore K. Kvien [Norvège] ; Eirik Klami Kristianslund [Norvège] ; Maria Jose Santos [Portugal] ; Žiga Rotar [Slovénie] ; Florenzo Iannone [Italie] ; Catalin Codreanu [Roumanie] ; Galina Lukina [Russie] ; Sara L. Gale [États-Unis] ; Khaled Sarsour [États-Unis] ; Yves Luder [Suisse] ; Delphine Sophie Courvoisier [Suisse] ; Cem Gabay [Suisse]

Source :

Annals of the rheumatic diseases [ 1468-2060 ] ; 2018.

RBID : pubmed:29730637

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps monoclonaux humanisés (usage thérapeutique), Antirhumatismaux (usage thérapeutique), Association de médicaments, Enregistrements, Estimation de Kaplan-Meier, Facteur de nécrose tumorale alpha (antagonistes et inhibiteurs), Femelle, Humains, Indice de gravité médicale, Modèles de hasards proportionnels, Mâle, Polyarthrite rhumatoïde (traitement médicamenteux), Résultat thérapeutique, Sujet âgé.
MESH :
- antagonistes et inhibiteurs : Facteur de nécrose tumorale alpha.
- traitement médicamenteux : Polyarthrite rhumatoïde.
- usage thérapeutique : Anticorps monoclonaux humanisés, Antirhumatismaux.
- Adulte, Adulte d'âge moyen, Association de médicaments, Enregistrements, Estimation de Kaplan-Meier, Femelle, Humains, Indice de gravité médicale, Modèles de hasards proportionnels, Mâle, Résultat thérapeutique, Sujet âgé.

English descriptors

KwdEn :
- Adult, Aged, Antibodies, Monoclonal, Humanized (therapeutic use), Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (drug therapy), Drug Therapy, Combination, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Proportional Hazards Models, Registries, Severity of Illness Index, Treatment Outcome, Tumor Necrosis Factor-alpha (antagonists & inhibitors).
MESH :
- chemical , antagonists & inhibitors : Tumor Necrosis Factor-alpha.
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Antirheumatic Agents.
- drug therapy : Arthritis, Rheumatoid.
- Adult, Aged, Drug Therapy, Combination, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Proportional Hazards Models, Registries, Severity of Illness Index, Treatment Outcome.

Abstract

To compare the effectiveness of tocilizumab (TCZ) and tumour necrosis factor (TNF) inhibitors (TNFi) as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA) after the use of at least one biologic DMARD (bDMARD).

DOI: 10.1136/annrheumdis-2017-212845
PubMed: 29730637

Affiliations:

Espagne, Finlande, Italie, Norvège, Portugal, Roumanie, Russie, République tchèque, Slovénie, Suisse, États-Unis
Bohême centrale, Californie, Catalogne, District fédéral central, Østlandet
Barcelone, Moscou, Oslo, Prague

Le document en format XML

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<author><name sortKey="Lauper, Kim" sort="Lauper, Kim" uniqKey="Lauper K" first="Kim" last="Lauper">Kim Lauper</name>
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<author><name sortKey="Kvien, Tore K" sort="Kvien, Tore K" uniqKey="Kvien T" first="Tore K" last="Kvien">Tore K. Kvien</name>
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<author><name sortKey="Kristianslund, Eirik Klami" sort="Kristianslund, Eirik Klami" uniqKey="Kristianslund E" first="Eirik Klami" last="Kristianslund">Eirik Klami Kristianslund</name>
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<author><name sortKey="Santos, Maria Jose" sort="Santos, Maria Jose" uniqKey="Santos M" first="Maria Jose" last="Santos">Maria Jose Santos</name>
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<author><name sortKey="Rotar, Ziga" sort="Rotar, Ziga" uniqKey="Rotar Z" first="Žiga" last="Rotar">Žiga Rotar</name>
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<country xml:lang="fr">Slovénie</country>
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<wicri:noRegion>Ljubljana</wicri:noRegion>
</affiliation>
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<author><name sortKey="Iannone, Florenzo" sort="Iannone, Florenzo" uniqKey="Iannone F" first="Florenzo" last="Iannone">Florenzo Iannone</name>
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<country xml:lang="fr">Italie</country>
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<author><name sortKey="Codreanu, Catalin" sort="Codreanu, Catalin" uniqKey="Codreanu C" first="Catalin" last="Codreanu">Catalin Codreanu</name>
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<author><name sortKey="Lukina, Galina" sort="Lukina, Galina" uniqKey="Lukina G" first="Galina" last="Lukina">Galina Lukina</name>
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<placeName><region type="state">Californie</region>
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<author><name sortKey="Sarsour, Khaled" sort="Sarsour, Khaled" uniqKey="Sarsour K" first="Khaled" last="Sarsour">Khaled Sarsour</name>
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<author><name sortKey="Luder, Yves" sort="Luder, Yves" uniqKey="Luder Y" first="Yves" last="Luder">Yves Luder</name>
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<author><name sortKey="Courvoisier, Delphine Sophie" sort="Courvoisier, Delphine Sophie" uniqKey="Courvoisier D" first="Delphine Sophie" last="Courvoisier">Delphine Sophie Courvoisier</name>
<affiliation wicri:level="1"><nlm:affiliation>Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Geneva University Hospitals, Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
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<author><name sortKey="Gabay, Cem" sort="Gabay, Cem" uniqKey="Gabay C" first="Cem" last="Gabay">Cem Gabay</name>
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<country xml:lang="fr">Suisse</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Comparative effectiveness of tocilizumab versus TNF inhibitors as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis after the use of at least one biologic disease-modifying antirheumatic drug: analyses from the pan-European TOCERRA register collaboration.</title>
<author><name sortKey="Lauper, Kim" sort="Lauper, Kim" uniqKey="Lauper K" first="Kim" last="Lauper">Kim Lauper</name>
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<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Geneva University Hospitals, Geneva</wicri:regionArea>
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<author><name sortKey="Nordstrom, Dan C" sort="Nordstrom, Dan C" uniqKey="Nordstrom D" first="Dan C" last="Nordström">Dan C. Nordström</name>
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<country xml:lang="fr">Finlande</country>
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<author><name sortKey="Pavelka, Karel" sort="Pavelka, Karel" uniqKey="Pavelka K" first="Karel" last="Pavelka">Karel Pavelka</name>
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<wicri:regionArea>Charles University, Prague</wicri:regionArea>
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<author><name sortKey="Hernandez, Maria Victoria" sort="Hernandez, Maria Victoria" uniqKey="Hernandez M" first="Maria Victoria" last="Hernández">Maria Victoria Hernández</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Rheumatology Department, Hospital Clinic Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
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<author><name sortKey="Kvien, Tore K" sort="Kvien, Tore K" uniqKey="Kvien T" first="Tore K" last="Kvien">Tore K. Kvien</name>
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<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Rheumatology, Diakonhjemmet Hospital, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kristianslund, Eirik Klami" sort="Kristianslund, Eirik Klami" uniqKey="Kristianslund E" first="Eirik Klami" last="Kristianslund">Eirik Klami Kristianslund</name>
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<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Rheumatology, Diakonhjemmet Hospital, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
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</author>
<author><name sortKey="Santos, Maria Jose" sort="Santos, Maria Jose" uniqKey="Santos M" first="Maria Jose" last="Santos">Maria Jose Santos</name>
<affiliation wicri:level="1"><nlm:affiliation>Rheumatology Department, Hospital Garcia de Orta, on behalf of Reuma.pt, Almada, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Rheumatology Department, Hospital Garcia de Orta, on behalf of Reuma.pt, Almada</wicri:regionArea>
<wicri:noRegion>Almada</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rotar, Ziga" sort="Rotar, Ziga" uniqKey="Rotar Z" first="Žiga" last="Rotar">Žiga Rotar</name>
<affiliation wicri:level="1"><nlm:affiliation>BioRx.si, University Medical Centre Ljubljana, Ljubljana, Slovenia.</nlm:affiliation>
<country xml:lang="fr">Slovénie</country>
<wicri:regionArea>BioRx.si, University Medical Centre Ljubljana, Ljubljana</wicri:regionArea>
<wicri:noRegion>Ljubljana</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Iannone, Florenzo" sort="Iannone, Florenzo" uniqKey="Iannone F" first="Florenzo" last="Iannone">Florenzo Iannone</name>
<affiliation wicri:level="1"><nlm:affiliation>GISEA, University Hospital of Bari, Bari, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>GISEA, University Hospital of Bari, Bari</wicri:regionArea>
<wicri:noRegion>Bari</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Codreanu, Catalin" sort="Codreanu, Catalin" uniqKey="Codreanu C" first="Catalin" last="Codreanu">Catalin Codreanu</name>
<affiliation wicri:level="1"><nlm:affiliation>Center of Rheumatic Diseases, University of Medicine and Pharmacy, Bucharest, Romania.</nlm:affiliation>
<country xml:lang="fr">Roumanie</country>
<wicri:regionArea>Center of Rheumatic Diseases, University of Medicine and Pharmacy, Bucharest</wicri:regionArea>
<wicri:noRegion>Bucharest</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lukina, Galina" sort="Lukina, Galina" uniqKey="Lukina G" first="Galina" last="Lukina">Galina Lukina</name>
<affiliation wicri:level="3"><nlm:affiliation>ARBITER, Institute of Rheumatology, Moscow, Russian Federation.</nlm:affiliation>
<country xml:lang="fr">Russie</country>
<wicri:regionArea>ARBITER, Institute of Rheumatology, Moscow</wicri:regionArea>
<placeName><settlement type="city">Moscou</settlement>
<region>District fédéral central</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gale, Sara L" sort="Gale, Sara L" uniqKey="Gale S" first="Sara L" last="Gale">Sara L. Gale</name>
<affiliation wicri:level="2"><nlm:affiliation>Genentech, South San Francisco, California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genentech, South San Francisco, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sarsour, Khaled" sort="Sarsour, Khaled" uniqKey="Sarsour K" first="Khaled" last="Sarsour">Khaled Sarsour</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genentech, South San Francisco, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Luder, Yves" sort="Luder, Yves" uniqKey="Luder Y" first="Yves" last="Luder">Yves Luder</name>
<affiliation wicri:level="1"><nlm:affiliation>F. Hoffmann-La Roche AG, Basel, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>F. Hoffmann-La Roche AG, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Courvoisier, Delphine Sophie" sort="Courvoisier, Delphine Sophie" uniqKey="Courvoisier D" first="Delphine Sophie" last="Courvoisier">Delphine Sophie Courvoisier</name>
<affiliation wicri:level="1"><nlm:affiliation>Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Geneva University Hospitals, Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gabay, Cem" sort="Gabay, Cem" uniqKey="Gabay C" first="Cem" last="Gabay">Cem Gabay</name>
<affiliation wicri:level="1"><nlm:affiliation>Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Geneva University Hospitals, Geneva</wicri:regionArea>
<wicri:noRegion>Geneva</wicri:noRegion>
</affiliation>
</author>
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<series><title level="j">Annals of the rheumatic diseases</title>
<idno type="eISSN">1468-2060</idno>
<imprint><date when="2018" type="published">2018</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Antibodies, Monoclonal, Humanized (therapeutic use)</term>
<term>Antirheumatic Agents (therapeutic use)</term>
<term>Arthritis, Rheumatoid (drug therapy)</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Proportional Hazards Models</term>
<term>Registries</term>
<term>Severity of Illness Index</term>
<term>Treatment Outcome</term>
<term>Tumor Necrosis Factor-alpha (antagonists & inhibitors)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps monoclonaux humanisés (usage thérapeutique)</term>
<term>Antirhumatismaux (usage thérapeutique)</term>
<term>Association de médicaments</term>
<term>Enregistrements</term>
<term>Estimation de Kaplan-Meier</term>
<term>Facteur de nécrose tumorale alpha (antagonistes et inhibiteurs)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Polyarthrite rhumatoïde (traitement médicamenteux)</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term>
<term>Antirheumatic Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Polyarthrite rhumatoïde</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term>
<term>Antirhumatismaux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Proportional Hazards Models</term>
<term>Registries</term>
<term>Severity of Illness Index</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Association de médicaments</term>
<term>Enregistrements</term>
<term>Estimation de Kaplan-Meier</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de gravité médicale</term>
<term>Modèles de hasards proportionnels</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To compare the effectiveness of tocilizumab (TCZ) and tumour necrosis factor (TNF) inhibitors (TNFi) as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA) after the use of at least one biologic DMARD (bDMARD).</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
<li>Finlande</li>
<li>Italie</li>
<li>Norvège</li>
<li>Portugal</li>
<li>Roumanie</li>
<li>Russie</li>
<li>République tchèque</li>
<li>Slovénie</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Bohême centrale</li>
<li>Californie</li>
<li>Catalogne</li>
<li>District fédéral central</li>
<li>Østlandet</li>
</region>
<settlement><li>Barcelone</li>
<li>Moscou</li>
<li>Oslo</li>
<li>Prague</li>
</settlement>
</list>
<tree><country name="Suisse"><noRegion><name sortKey="Lauper, Kim" sort="Lauper, Kim" uniqKey="Lauper K" first="Kim" last="Lauper">Kim Lauper</name>
</noRegion>
<name sortKey="Courvoisier, Delphine Sophie" sort="Courvoisier, Delphine Sophie" uniqKey="Courvoisier D" first="Delphine Sophie" last="Courvoisier">Delphine Sophie Courvoisier</name>
<name sortKey="Gabay, Cem" sort="Gabay, Cem" uniqKey="Gabay C" first="Cem" last="Gabay">Cem Gabay</name>
<name sortKey="Luder, Yves" sort="Luder, Yves" uniqKey="Luder Y" first="Yves" last="Luder">Yves Luder</name>
</country>
<country name="Finlande"><noRegion><name sortKey="Nordstrom, Dan C" sort="Nordstrom, Dan C" uniqKey="Nordstrom D" first="Dan C" last="Nordström">Dan C. Nordström</name>
</noRegion>
</country>
<country name="République tchèque"><region name="Bohême centrale"><name sortKey="Pavelka, Karel" sort="Pavelka, Karel" uniqKey="Pavelka K" first="Karel" last="Pavelka">Karel Pavelka</name>
</region>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="Hernandez, Maria Victoria" sort="Hernandez, Maria Victoria" uniqKey="Hernandez M" first="Maria Victoria" last="Hernández">Maria Victoria Hernández</name>
</region>
</country>
<country name="Norvège"><region name="Østlandet"><name sortKey="Kvien, Tore K" sort="Kvien, Tore K" uniqKey="Kvien T" first="Tore K" last="Kvien">Tore K. Kvien</name>
</region>
<name sortKey="Kristianslund, Eirik Klami" sort="Kristianslund, Eirik Klami" uniqKey="Kristianslund E" first="Eirik Klami" last="Kristianslund">Eirik Klami Kristianslund</name>
</country>
<country name="Portugal"><noRegion><name sortKey="Santos, Maria Jose" sort="Santos, Maria Jose" uniqKey="Santos M" first="Maria Jose" last="Santos">Maria Jose Santos</name>
</noRegion>
</country>
<country name="Slovénie"><noRegion><name sortKey="Rotar, Ziga" sort="Rotar, Ziga" uniqKey="Rotar Z" first="Žiga" last="Rotar">Žiga Rotar</name>
</noRegion>
</country>
<country name="Italie"><noRegion><name sortKey="Iannone, Florenzo" sort="Iannone, Florenzo" uniqKey="Iannone F" first="Florenzo" last="Iannone">Florenzo Iannone</name>
</noRegion>
</country>
<country name="Roumanie"><noRegion><name sortKey="Codreanu, Catalin" sort="Codreanu, Catalin" uniqKey="Codreanu C" first="Catalin" last="Codreanu">Catalin Codreanu</name>
</noRegion>
</country>
<country name="Russie"><region name="District fédéral central"><name sortKey="Lukina, Galina" sort="Lukina, Galina" uniqKey="Lukina G" first="Galina" last="Lukina">Galina Lukina</name>
</region>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Gale, Sara L" sort="Gale, Sara L" uniqKey="Gale S" first="Sara L" last="Gale">Sara L. Gale</name>
</region>
<name sortKey="Sarsour, Khaled" sort="Sarsour, Khaled" uniqKey="Sarsour K" first="Khaled" last="Sarsour">Khaled Sarsour</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Comparative effectiveness of tocilizumab versus TNF inhibitors as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis after the use of at least one biologic disease-modifying antirheumatic drug: analyses from the pan-European TOCERRA register collaboration.
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